Peer Reviewed Journal Articles

1. Pereles, R.S.*, J. Roy*, M.D. Brooks, M.S. Wicha, J.S. Jeruss, L.D. Shea, S.M. Orbach, “Dynamic Immune Cell Composition, Phenotypes, and Signaling in an Engineered Metastatic Niche”, Biotechnology and Bioengineering, 2026.
    

2. Ma, J.A., S.M. Orbach, K.V. Griffin, K. Kang, Y. Zhang, R.S. Pereles, I.A. Shrack, G. Escalona, J.S. Jeruss, L.D. Shea, “Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles”, Molecular Oncology, 2025.
    

3. Rad, L.M., K.R. Hughes, S.N. Wheeler, J.T. Decker, S.M. Orbach, A. Galvan, J.M. Thornhill, K.V. Griffin, H. Turkistani, R.R. Urie, D.N. Irani, L.D. Shea, A.H. Morris, "Engineered immunological niche directs therapeutic development in models of progressive multiple sclerosis", PNAS, 2025.
    

4. Decker, J.T., M.S. Hall, D. Nanua, S.M. Orbach, J. Roy, A. Angadi, J. Caton, L. Hesse, J.S. Jeruss, L.D. Shea, “Dynamic transcriptional programs during single NK cell killing: connecting form to function in cellular immunotherapy”, Cellular and Molecular Bioengineering, 2024.
    

5. Orbach, S.M., C.Y. DeVaull, E.J. Bealer, B.C. Ross, J.S. Jeruss, L.D. Shea., “An engineered niche delineates metastatic potential of breast cancer”, Bioengineering & Translational Medicine, 2024.
    

6. Wang, J., R. Ocadiz-Ruiz, M.S. Hall, G.G. Bushnell, S.M. Orbach, J.T. Decker, R.M. Raghani, Y. Zhang, A.H. Morris, J.S. Jeruss, L.D. Shea, “A synthetic metastatic niche reveals antitumor neutrophils drive breast cancer metastatic dormancy in the lungs”, Nature Communications, 2023.
    

7. Law, J.N., S.M. Orbach, B.R. Weston, P.A. Steele, P. Rajagopalan, T.M. Murali, “Computational Construction of Toxicant Signaling Networks”, Chemical Research in Toxicology, 2023.
    

8. Raghani, R.M.*, J.A. Ma*, Y. Zhang, S.M. Orbach, J. Wang, M. Zeinali, S. Nagrath, S. Kakade, Q. Xu, J.R. Podojil, T. Murthy, A. Elhofy, J.S. Jeruss, L.D. Shea, “Myeloid cell reprogramming alleviates immunosuppression and promotes clearance of metastatic lesions”, Frontiers in Oncology, 2022.
    

9. Orbach, S.M., M.D. Brooks, Y. Zhang, S.E. Campit, G.G. Bushnell, J.D. Decker, R.J. Rebernick, S. Chandrasekaran, M.S. Wicha, J.S. Jeruss, L.D. Shea, “Single-cell RNA sequencing identifies anti-cancer immune phenotypes in the early lung metastatic niche during breast cancer”, Clinical and Experimental Metastasis, 2022.
    

10. Podojil, J.R., A.C. Cogswell, M. Chiang, V. Eaton, I. Ifergan, T. Neef, D. Xu, K.A. Meghani, Y. Yu, S.M. Orbach, T. Murthy, M.T. Boyne, A. Elhofy, L.D. Shea, J.J. Meeks, S.D. Miller, “Biodegradable nanoparticles induce cGAS/STING-dependent reprogramming of myeloid cells to promote tumor immunotherapy”, Frontiers in Immunology, 2022.
     

11. Kemp, S.B., N.G. Steele, E.S. Carpenter, K.L. Donahue, G.G. Bushnell, A.H. Morris, S. The, S.M. Orbach, V.R. Sirigorachai, Z.C. Nwosu, C. Espinoza, F. Lima, K. Brown, A.A. Girgis, V. Gunchick, Y. Zhang, C.A. Lyssiotis, T.L. Frankel, F. Bednar, A. Rao, V. Sahai, L.D. Shea, H.C. Crawford, M.P. di Magliano, “Pancreatic cancer is marked by complement-high blood monocytes and tumor-associated macrophages”, Life Science Alliance, 2021.
     

12. Zhang, Y., K.R. Hughes, R.M. Raghani, J.A. Ma, S.M. Orbach, J.S. Jeruss, L.D. Shea, “Cargo-free immunomodulatory nanoparticles combined with anti-PD-1 antibody for treating metastatic breast cancer”, Biomaterials, 2021.
     

13. Orbach, S.M.*, G.G. Bushnell*, J.A. Ma, H.C. Crawford, M.S. Wicha, J.S. Jeruss, L.D. Shea, “Disease-induced immunomodulation at biomaterial scaffolds detects early pancreatic cancer in a spontaneous model”, Biomaterials, 2021.
     

14. Morris, A.H., S.M. Orbach, G.G. Bushnell, R.S. Oakes, J.S. Jeruss, L.D. Shea, “Engineered Niches to Analyze Mechanisms of Metastasis and Guide Precision Medicine”, Cancer Research, 2020.
     

15. Oakes, R.S., G.G. Bushnell, S.M. Orbach, P. Kandagatla, Y. Zhang, A.H. Morris, M.S. Hall, P. LaFaire, J.T. Decker, R.M. Hartfield, M.D. Brooks, M.S. Wicha, J.S. Jeruss, L.D. Shea, “Metastatic conditioning of myeloid cells at a subcutaneous synthetic niche reflects disease progression and predicts therapeutic outcomes”, Cancer Research, 2020.
     

16. Ford, A.J., S.M. Orbach, P. Rajagopalan, “Fibroblasts stimulate macrophage migration in interconnected extracellular matrices through tunnel formation and fiber alignment”, Biomaterials, 2019.
     

17. Orbach, S.M., A.J. Ford, S.E. Saverot, P. Rajagopalan, “Multi-cellular transitional organotypic models to investigate liver fibrosis”, Acta Biomaterialia, 2018.
     

18. Orbach S.M., M.F. Ehrich, P. Rajagopalan, “High-throughput Toxicity Testing of Chemicals and Mixtures in Organotypic Multi-Cellular Cultures of Primary Human Hepatic Cells”, Toxicology in Vitro, 2018.
     

19. Orbach, S.M., R.R. Less, A. Kothari, P. Rajagopalan, “In Vitro Intestinal and Liver Models for Toxicity Testing”, ACS Biomaterials Science & Engineering, 2017.
     

20. Orbach, S.M., M.E. Cassin, M.F. Ehrich, P. Rajagopalan, “Investigating Acetaminophen Hepatotoxicity in Multi-Cellular Organotypic Liver Models”, Toxicology in Vitro, 2017.
     

21. Vu L.T., S.M. Orbach, W.K. Ray, M.E. Cassin, P. Rajagopalan, R.F. Helm, “The Hepatocyte Proteome in Organotypic Rat Liver Models and the Influence of the Local Microenvironment”, Proteome Science, 2016.
     

22. Cassin, M.E., A.J. Ford, S.M. Orbach, S.E. Saverot, P. Rajagopalan, “The Design of Antimicrobial LL37-Modified Collagen-Hyaluronic Acid Detachable Multilayers”, Acta Biomaterialia, 2016.